Experience Biopharm Workshop 2

Method Development and Scale-up of Ion Exchange Chromatography

This hands-on course introduces tools for the development and scale up of protein separations, focusing on ion exchange chromatography. The combination of theoretical lectures, industrial case studies and experiments in the lab enables participants to understand and use systematic models and methodologies to develop ion exchange unit operations and transfer these processes from lab to pilot plant or production scale.
 

WORKSHOP CONTENT

Basic principles of protein purification and column chromatography
Theory and Application of the linear gradient elution (LGE) model for optimization and scale-up of ion exchange chromatography
Case studies presented by experts from industry
Aspects of resin selection, column packing and large-scale manufacturing

LEARNING GOALS

Understanding of process parameters critical to ion exchange chromatography at small and large scale
Understanding of principles of gradient elution processes and the LGE model
Practical optimization and scale up of ion exchange separations using the LGE model

WHO SHOULD ATTEND?

Process development scientists
R&D scientists and technicians
Process engineers involved in scale up and manufacturing of ion exchange chromatography unit operations

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