Experience Biopharm

Das Steinbeis Transferzentrum bietet in Kooperation mit MERCK KGaA zwei Workshops an.

Workshop 1: Chromatographic Methods, Strategies and Optimization

This hands-on course provides a fundamental understanding of chromatographic methods and strategies to purify monoclonal antibodies and related molecules. The combination of theoretical lectures, industrial case studies, and experiments in the lab enables participants to gain a profound knowledge of biochromatography processes.

Inhalt des Workshops

Theory and application of Protein A, ion exchange, and mixed-mode chromatography
Purification strategies for antibodies and related molecules
Case studies presented by experts from the industry
Quality and safety aspects

Lernziele

Designing robust chromatographic unit operations
Defining and optimizing suitable purification strategies
Evaluating the pros and cons of different techniques
Selecting analytical tools for process development
Understand and use all the tools needed to remove process impurities and contaminants

Wer sollte teilnehmen?

Process development scientists
Chemical and biochemical engineers
R&D scientists and technicians
Professionals in areas related to antibody processing

Workshop 2: Method Development and Scale-up of Ion Exchange Chromatography

This hands-on course introduces tools for the development and scale up of protein separations, focusing on ion exchange chromatography. The combination of theoretical lectures, industrial case studies and experiments in the lab enables participants to understand and use systematic models and methodologies to develop ion exchange unit operations and transfer these processes from lab to pilot plant or production scale.

Inhalt des Workshops

Basic principles of protein purification and column chromatography
Theory and Application of the linear gradient elution (LGE) model for optimization and scale-up of ion exchange chromatography
Case studies presented by experts from industry
Aspects of resin selection, column packing and large-scale manufacturing

Lernziele

Understanding of process parameters critical to ion exchange chromatography at small and large scale
Understanding of principles of gradient elution processes and the LGE model
Practical optimization and scale up of ion exchange separations using the LGE model

Wer sollte teilnehmen?

Process development scientists
R&D scientists and technicians
Process engineers involved in scale up and manufacturing of ion exchange chromatography unit operations